Tonight at 8pm the historic rivals will battle it out at Wembley in their second game in the European Championship.
England had a strong start in the Euros this year, winning the opening game of a European Championship for the first time ever, while Scotland lost 2-0 to the Czech Republic.
If England win, they get through to the knockout rounds.
With reports of up to 20,000 Scottish fans descending on London for the game, there's a lot to play for.
Who do you think will win? What are your score predictions?
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